Functional aspects of mouse islets transplanted to the kidney
نویسندگان
چکیده
منابع مشابه
Evidence of functional impairment of syngeneically transplanted mouse pancreatic islets retrieved from the liver.
A drawback in pancreatic islet transplantation is the large number of islets needed to obtain insulin independence in patients with diabetes. This most likely reflects extensive posttransplantation islet cell death and functional impairment of the remaining endocrine cells. We aimed to develop an experimental method to retrieve transplanted islets from the mouse liver, which would enable compar...
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Pancreatic islets are highly vascularized, which is important in their ability to quickly secrete insulin in response to changes in blood glucose. Although pancreatic islets comprise only 1–2% of pancreatic mass, they receive 5–10% of pancreatic blood flow. Blood vessels within pancreatic islets are of a greater density than those in surrounding exocrine tissue and are lined with fenestrated en...
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Transplantation of islet or beta cells is seen as the cure for type 1 diabetes since it allows physiological regulation of blood glucose levels without requiring any compliance from the patients. In order to circumvent the use of immunosuppressive drugs (and their side effects), semipermeable membranes have been developed to encapsulate and immunoprotect transplanted cells. This review presents...
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15 صفحه اولMRI of transplanted pancreatic islets.
A promising treatment method for type 1 diabetes mellitus is transplantation of pancreatic islets containing beta-cells. The aim of this study was to develop an MR technique to monitor the distribution and fate of transplanted pancreatic islets in an animal model. Twenty-five hundred purified and magnetically labeled islets were transplanted through the portal vein into the liver of experimenta...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 1994
ISSN: 0012-186X,1432-0428
DOI: 10.1007/bf00400834